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|Section2= |Section3= }} Octyl glucoside (''n''-octyl-β-D-glucoside) is a detergent frequently used to solubilise integral membrane proteins for studies in biochemistry. Like Genapol X-100 and Triton X-100, it is a nonphysiological amphiphile that makes lipid bilayers less "stiff". It has become one of the most important detergents for purification of membrane proteins because it generally does not denature the protein and can readily be removed from final protein extracts. Above its critical micelle concentration of 0.7%, it was noted as the best detergent for improving selectivity of immunoprecipitation of phosphotyrosine modified proteins. This detergent has also been shown to rapidly inactivate infective HIV at concentrations above its CMC, about 0.7% (w/v) The compound gained popularity with researchers following the publication of an improved synthesis in 1978.〔See (PubMed ) search for "octyl() AND glucoside()" for a timeline of publications.〕 However, in 1990 the cost remained prohibitive for large-scale protein isolation.〔 〕 Octyl glucoside has been proposed as a conditioning agent to prevent microbial colonization of contact lenses, due to its ability to lower the hydrophobicity of contact lenses and prevent adhesion of ''Staphylococcus epidermidis'' and ''Pseudomonas aeruginosa''.〔 〕 ==See also== * Decyl glucoside * Lauryl glucoside * Alkyl polyglycoside * octyl thioglucoside 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Octyl glucoside」の詳細全文を読む スポンサード リンク
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